Welcome to Pathology's Bi-Weekly Bulletin | Sept 06, 2024

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Weekly Province-wide Pathology Rounds Return

Date: Friday, September 6th
Presentation Title: "B cell responses to lung cancer"
Presenter: Dr. Katey Enfield, PhD, Assistant Professor, BC Cancer Research, Pathology and Laboratory Medicine, UBC

Key Learning Objectives:

  • Understand how B cell responses in lung cancer involve tumour-specific antibodies that recognize deregulated self-antigens, including endogenous retroviruses, and their relevance to immunotherapy.
  • Learn how spatial analysis of the lung tumour microenvironment complements cancer genomics and reveals multicellular communities linked to key immunotherapy features, such as neoantigen burden.

You can also view previous rounds here. Rounds.

We welcome your participation and suggestions for topics or speakers. Please email your ideas to pathassist@pathology.ubc.ca.

The same Zoom link will be used for all rounds: Join Zoom Meeting
https://ubc.zoom.us/j/61199076992?pwd=3Ix1R2FwPB9rwimuOEfPmfhaO6onAa.1

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Dr. Torsten Nielsen Elected to the Royal Society of Canada

Congratulations to our professor, Dr. Torsten Nielsen, on being named a Fellow of the Royal Society of Canada for his outstanding contributions to pathology and laboratory medicine. He joins a group of UBC faculty members recognized for their remarkable achievements. Read more.

Breakthrough in Childhood Cancer Treatment

UBC Pathology professor Dr. Poul Sorensen and his team have discovered a drug that could prevent the spread of osteosarcoma, the most common childhood bone cancer. The drug reduces lung metastasis by over 90% while also shrinking the primary tumor. The team is now working to advance this discovery to clinical trials. Read more.

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Update on BMLSc Co-op

BMLSc Co-op Student: Vivian’s Story

Vivian, a 4th-year BMLSc student, secured a Co-op placement at ALS Global (Geochemistry) this summer. She shares how Co-op has helped her grow personally and professionally, while gaining hands-on experience in the field. Vivian's full story.

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Virtual Info Sessions for 2025 CaRMS Applicants

We are hosting a series of virtual info sessions for 2025 CaRMS applicants in early October. Each session will feature program directors, associate directors, and lead residents from various residency programs, including Hematopathology, Medical Microbiology, Neuropathology, and Diagnostic and Molecular Pathology.
For more details and to register, visit the info sessions page.

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Notable Cases by Dr. Habib Moshref Razavi:

A 54-year-old male with a history of cardiovascular disease presented with intermittent fevers, chills, and dizziness. Two weeks prior, he had been gardening in Pemberton, BC, where he developed a red, pruritic rash on his arms following multiple bug bites. Although he did not observe a tick or erythema migrans, the rash resolved within days. His initial symptoms were attributed to heat exposure, but he soon experienced recurrent fevers, night sweats, dry cough, and cervical lymphadenopathy. These symptoms temporarily improved with over-the-counter medications but later worsened, leading to near-syncope and chest pain.

Upon presentation, his physical exam was largely unremarkable aside from small petechiae on his right leg and a subcutaneous nodule on his forearm. Blood film examination revealed numerous spirochetes, raising suspicion for a tick-borne illness. Serological testing for Lyme disease (Borrelia burgdorferi) and Borrelia hermsii (responsible for tick-borne relapsing fever) was initiated, given the patient’s exposure history and clinical presentation.

This case highlights the importance of considering tick-borne illnesses in patients with recent outdoor exposure and nonspecific symptoms. A 14-day course of doxycycline was recommended to cover both Borrelia species, with follow-up testing pending to confirm the diagnosis.

Key takeaway: Be vigilant for vector-borne infections, even in regions where Lyme disease is not endemic. (May-Grünwald Giemsa stain x100 magnification). hematology#, hematopathology#, pathology#, parasites#, tickborne illness#, morphology#.